Archive for the ‘Health’ Category

Kaiser Permanente recognized for having one of California’s best Medicare Advantage health plans

Thursday, October 28th, 2021

Follows Kaiser Permanente’s Medicare health plan in California receiving a 5 out of 5-star rating making it among the highest rated in the nation

By Antonia Ehlers, PR and Media Relations, Kaiser Permanente Northern California

Kaiser Permanente’s Medicare Advantage health plan is one of the best in California for quality care and service, according to U.S. News & World Report’s Best Insurance Companies for Medicare Advantage Plans 2022.

To create its 2022 list of best insurance companies for Medicare Advantage, U.S. News & World Report analyzed Medicare Advantage offerings in each state based on the Centers for Medicare & Medicaid Services (CMS) annual Star Quality Ratings for 2022.

In the CMS 2022 ratings, Kaiser Permanente’s Medicare health plan in California received a 5 out of 5-star rating – making it among the highest rated in the nation – for providing expert medicine, seamless care, and outstanding service to its Medicare health plan members. This is the 11th straight year Kaiser Permanente’s Medicare health plan in California has been rated 5 out of 5 stars.

According to U.S. News & World Report, a “best” Medicare Advantage insurance company is defined as a health care organization whose plans were all rated at least 3 out of 5 stars by CMS and whose plans have an average rating of 4.5 or more stars within the state.

With Kaiser Permanente, Medicare members get high-quality medical services, hospital care, prescription drug coverage, preventive care, and more in one easy-to-use plan. We also offer convenient care options, such as video visits, phone appointments, and secure email.

Learn more about Medicare, explore Kaiser Permanente’s Medicare Advantage plans, and get information on enrolling. 

About Kaiser Permanente

Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America’s leading health care providers and not-for-profit health plans. Founded in 1945, Kaiser Permanente has a mission to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve almost 12.5 million members in 8 states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal Permanente Medical Group physicians, specialists, and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the-art care delivery, and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education, and the support of community health. http://about.kaiserpermanente.org

 

91 research studies affirm naturally acquired immunity to COVID-19: Documented, linked, and quoted

Wednesday, October 27th, 2021

BY PAUL ELIAS ALEXANDER

This article was first published by Brownstone Institute. Republished with permission.

We should not force COVID vaccines on anyone when the evidence shows that naturally acquired immunity is equal to or more robust and superior to existing vaccines. Instead, we should respect the right of the bodily integrity of individuals to decide for themselves.

Public health officials and the medical establishment with the help of the politicized media are misleading the public with assertions that the COVID-19 shots provide greater protection than natural immunity.  CDC Director Rochelle Walensky, for example, was deceptive in her October 2020 published LANCET statement that “there is no evidence for lasting protective immunity to SARS-CoV-2 following natural infection” and that “the consequence of waning immunity would present a risk to vulnerable populations for the indefinite future.”

Immunology and virology 101 have taught us over a century that natural immunity confers protection against a respiratory virus’s outer coat proteins, and not just one, e.g. the SARS-CoV-2 spike glycoprotein. There is even strong evidence for the persistence of antibodies. Even the CDC recognizes natural immunity for chicken-pox and measles, mumps, and rubella, but not for COVID-19.

The vaccinated are showing viral loads (very high) similar to the unvaccinated (Acharya et al. and Riemersma et al.), and the vaccinated are as infectious. Riemersma et al. also report Wisconsin data that corroborate how the vaccinated individuals who get infected with the Delta variant can potentially (and are) transmit(ting) SARS-CoV-2 to others (potentially to the vaccinated and unvaccinated).

This troubling situation of the vaccinated being infectious and transmitting the virus emerged in seminal nosocomial outbreak papers by Chau et al. (HCWs in Vietnam), the Finland hospital outbreak (spread among HCWs and patients), and the Israel hospital outbreak (spread among HCWs and patients). These studies also revealed that the PPE and masks were essentially ineffective in the healthcare setting. Again, the Marek’s disease in chickens and the vaccination situation explains what we are potentially facing with these leaky vaccines (increased transmission, faster transmission, and more ‘hotter’ variants).

Moreover, existing immunity should be assessed before any vaccination, via an accurate, dependable, and reliable antibody test (or T cell immunity test) or be based on documentation of prior infection (a previous positive PCR or antigen test). Such would be evidence of immunity that is equal to that of vaccination and the immunity should be provided the same societal status as any vaccine-induced immunity. This will function to mitigate the societal anxiety with these forced vaccine mandates and societal upheaval due to job loss, denial of societal privileges etc. Tearing apart the vaccinated and the unvaccinated in a society, separating them, is not medically or scientifically supportable.

The Brownstone Institute previously documented 30 studies on natural immunity as it relates to Covid-19.

This follow-up chart is the most updated and comprehensive library list of 91 of the highest-quality, complete, most robust scientific studies and evidence reports/position statements on natural immunity as compared to the COVID-19 vaccine-induced immunity and allow you to draw your own conclusion.

I’ve benefited from the input of many to put this together, especially my co-authors:

  • Harvey Risch, MD, PhD (Yale School of Public Health)
  • Howard Tenenbaum, PhD ( Faculty of Medicine, University of Toronto)
  • Ramin Oskoui, MD (Foxhall Cardiology, Washington)
  • Peter McCullough, MD (Truth for Health Foundation (TFH)), Texas
  • Parvez Dara, MD (consultant, Medical Hematologist and Oncologist)

Evidence on natural immunity versus COVID-19 vaccine induced immunity as of October 15, 2021:

Study / report title, author, and year published Predominant finding on natural immunity
1) Necessity of COVID-19 vaccination in previously infected individuals, Shrestha, 2021 “Cumulative incidence of COVID-19 was examined among 52,238 employees in an American healthcare system. The cumulative incidence of SARS-CoV-2 infection remained almost zero among previously infected unvaccinated subjects, previously infected subjects who were vaccinated, and previously uninfected subjects who were vaccinated, compared with a steady increase in cumulative incidence among previously uninfected subjects who remained unvaccinated. Not one of the 1359 previously infected subjects who remained unvaccinated had a SARS-CoV-2 infection over the duration of the study. Individuals who have had SARS-CoV-2 infection are unlikely to benefit from COVID-19 vaccination…”
2) SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls, Le Bert, 2020 “Studied T cell responses against the structural (nucleocapsid (N) protein) and non-structural (NSP7 and NSP13 of ORF1) regions of SARS-CoV-2 in individuals convalescing from coronavirus disease 2019 (COVID-19) (n = 36). In all of these individuals, we found CD4 and CD8 T cells that recognized multiple regions of the N protein…showed that patients (n = 23) who recovered from SARS possess long-lasting memory T cells that are reactive to the N protein of SARS-CoV 17 years after the outbreak of SARS in 2003; these T cells displayed robust cross-reactivity to the N protein of SARS-CoV-2.”
3) Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections,Gazit, 2021 “A retrospective observational study comparing three groups: (1) SARS-CoV-2-naïve individuals who received a two-dose regimen of the BioNTech/Pfizer mRNA BNT162b2 vaccine, (2) previously infected individuals who have not been vaccinated, and (3) previously infected and single dose vaccinated individuals found para a 13 fold increased risk of breakthrough Delta infections in double vaccinated persons, and a 27 fold increased risk for symptomatic breakthrough infection in the double vaccinated relative to the natural immunity recovered persons…the risk of hospitalization was 8 times higher in the double vaccinated (para)…this analysis demonstrated that natural immunity affords longer lasting and stronger protection against infection, symptomatic disease and hospitalization due to the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity.”
4) Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection, Le Bert, 2021 “Studied SARS-CoV-2–specific T cells in a cohort of asymptomatic (n = 85) and symptomatic (n = 75) COVID-19 patients after seroconversion…thus, asymptomatic SARS-CoV-2–infected individuals are not characterized by weak antiviral immunity; on the contrary, they mount a highly functional virus-specific cellular immune response.”
5) Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection, Israel, 2021 “A total of 2,653 individuals fully vaccinated by two doses of vaccine during the study period and 4,361 convalescent patients were included. Higher SARS-CoV-2 IgG antibody titers were observed in vaccinated individuals (median 1581 AU/mL IQR [533.8-5644.6]) after the second vaccination, than in convalescent individuals (median 355.3 AU/mL IQR [141.2-998.7]; p<0.001). In vaccinated subjects, antibody titers decreased by up to 40% each subsequent month while in convalescents they decreased by less than 5% per month…this study demonstrates individuals who received the Pfizer-BioNTech mRNA vaccine have different kinetics of antibody levels compared to patients who had been infected with the SARS-CoV-2 virus, with higher initial levels but a much faster exponential decrease in the first group”.
6) SARS-CoV-2 re-infection risk in Austria, Pilz, 2021 Researchers recorded “40 tentative re-infections in 14, 840 COVID-19 survivors of the first wave (0.27%) and 253 581 infections in 8, 885, 640 individuals of the remaining general population (2.85%) translating into an odds ratio (95% confidence interval) of 0.09 (0.07 to 0.13)…relatively low re-infection rate of SARS-CoV-2 in Austria. Protection against SARS-CoV-2 after natural infection is comparable with the highest available estimates on vaccine efficacies.” Additionally, hospitalization in only five out of 14,840 (0.03%) people and death in one out of 14,840 (0.01%) (tentative re-infection).
7) mRNA vaccine-induced SARS-CoV-2-specific T cells recognize B.1.1.7 and B.1.351 variants but differ in longevity and homing properties depending on prior infection status, Neidleman, 2021 “Spike-specific T cells from convalescent vaccinees differed strikingly from those of infection-naïve vaccinees, with phenotypic features suggesting superior long-term persistence and ability to home to the respiratory tract including the nasopharynx. These results provide reassurance that vaccine-elicited T cells respond robustly to the B.1.1.7 and B.1.351 variants, confirm that convalescents may not need a second vaccine dose.”
8) Good news: Mild COVID-19 induces lasting antibody protection, Bhandari, 2021 “Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine in St. Louis. Such cells could persist for a lifetime, churning out antibodies all the while. The findings, published May 24 in the journal Nature, suggest that mild cases of COVID-19 leave those infected with lasting antibody protection and that repeated bouts of illness are likely to be uncommon.”
9) Robust neutralizing antibodies to SARS-CoV-2 infection persist for months, Wajnberg, 2021 “Neutralizing antibody titers against the SARS-CoV-2 spike protein persisted for at least 5 months after infection. Although continued monitoring of this cohort will be needed to confirm the longevity and potency of this response, these preliminary results suggest that the chance of reinfection may be lower than is currently feared.”
10) Evolution of Antibody Immunity to SARS-CoV-2, Gaebler, 2020 “Concurrently, neutralizing activity in plasma decreases by five-fold in pseudo-type virus assays. In contrast, the number of RBD-specific memory B cells is unchanged. Memory B cells display clonal turnover after 6.2 months, and the antibodies they express have greater somatic hypermutation, increased potency and resistance to RBD mutations, indicative of continued evolution of the humoral response…we conclude that the memory B cell response to SARS-CoV-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence.”
11) Persistence of neutralizing antibodies a year after SARS-CoV-2 infection in humans, Haveri, 2021 “Assessed the persistence of serum antibodies following WT SARS-CoV-2 infection at 8 and 13 months after diagnosis in 367 individuals…found that NAb against the WT virus persisted in 89% and S-IgG in 97% of subjects for at least 13 months after infection.”
12) Quantifying the risk of SARS‐CoV‐2 reinfection over time, Murchu, 2021 “Eleven large cohort studies were identified that estimated the risk of SARS‐CoV‐2 reinfection over time, including three that enrolled healthcare workers and two that enrolled residents and staff of elderly care homes. Across studies, the total number of PCR‐positive or antibody‐positive participants at baseline was 615,777, and the maximum duration of follow‐up was more than 10 months in three studies. Reinfection was an uncommon event (absolute rate 0%–1.1%), with no study reporting an increase in the risk of reinfection over time.”
13) Natural immunity to covid is powerful. Policymakers seem afraid to say so, Makary, 2021 Makary writes “it’s okay to have an incorrect scientific hypothesis. But when new data proves it wrong, you have to adapt. Unfortunately, many elected leaders and public health officials have held on far too long to the hypothesis that natural immunity offers unreliable protection against covid-19 — a contention that is being rapidly debunked by science. More than 15 studies have demonstrated the power of immunity acquired by previously having the virus. A 700,000-person study from Israel two weeks ago found that those who had experienced prior infections were 27 times less likely to get a second symptomatic covid infection than those who were vaccinated. This affirmed a June Cleveland Clinic study of health-care workers (who are often exposed to the virus), in which none who had previously tested positive for the coronavirus got reinfected. The study authors concluded that “individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.” And in May, a Washington University study found that even a mild covid infection resulted in long-lasting immunity.”
14) SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity, Nielsen, 2021 “203 recovered SARS-CoV-2 infected patients in Denmark between April 3rd and July 9th 2020, at least 14 days after COVID-19 symptom recovery… report broad serological profiles within the cohort, detecting antibody binding to other human coronaviruses… the viral surface spike protein was identified as the dominant target for both neutralizing antibodies and CD8+ T-cell responses. Overall, the majority of patients had robust adaptive immune responses, regardless of their disease severity.”
15) Protection of previous SARS-CoV-2 infection is similar to that of BNT162b2 vaccine protection: A three-month nationwide experience from Israel, Goldberg, 2021 “Analyze an updated individual-level database of the entire population of Israel to assess the protection efficacy of both prior infection and vaccination in preventing subsequent SARS-CoV-2 infection, hospitalization with COVID-19, severe disease, and death due to COVID-19… vaccination was highly effective with overall estimated efficacy for documented infection of 92·8% (CI:[92·6, 93·0]); hospitalization 94·2% (CI:[93·6, 94·7]); severe illness 94·4% (CI:[93·6, 95·0]); and death 93·7% (CI:[92·5, 94·7]). Similarly, the overall estimated level of protection from prior SARS-CoV-2 infection for documented infection is 94·8% (CI: [94·4, 95·1]); hospitalization 94·1% (CI: [91·9, 95·7]); and severe illness 96·4% (CI: [92·5, 98·3])…results question the need to vaccinate previously-infected individuals.”
16) Incidence of Severe Acute Respiratory Syndrome Coronavirus-2 infection among previously infected or vaccinated employees, Kojima, 2021 “Employees were divided into three groups: (1) SARS-CoV-2 naïve and unvaccinated, (2) previous SARS-CoV-2 infection, and (3) vaccinated. Person-days were measured from the date of the employee first test and truncated at the end of the observation period. SARS-CoV-2 infection was defined as two positive SARS-CoV-2 PCR tests in a 30-day period… 4313, 254 and 739 employee records for groups 1, 2, and 3…previous SARS-CoV-2 infection and vaccination for SARS-CoV-2 were associated with decreased risk for infection or re-infection with SARS-CoV-2 in a routinely screened workforce. The was no difference in the infection incidence between vaccinated individuals and individuals with previous infection.”
17) Having SARS-CoV-2 once confers much greater immunity than a vaccine—but vaccination remains vital, Wadman, 2021 “Israelis who had an infection were more protected against the Delta coronavirus variant than those who had an already highly effective COVID-19 vaccine…the newly released data show people who once had a SARS-CoV-2 infection were much less likely than never-infected, vaccinated people to get Delta, develop symptoms from it, or become hospitalized with serious COVID-19.”
18) One-year sustained cellular and humoral immunities of COVID-19 convalescents, Zhang, 2021 “A systematic antigen-specific immune evaluation in 101 COVID-19 convalescents; SARS-CoV-2-specific IgG antibodies, and also NAb can persist among over 95% COVID-19 convalescents from 6 months to 12 months after disease onset. At least 19/71 (26%) of COVID-19 convalescents (double positive in ELISA and MCLIA) had detectable circulating IgM antibody against SARS-CoV-2 at 12m post-disease onset. Notably, the percentages of convalescents with positive SARS-CoV-2-specific T-cell responses (at least one of the SARS-CoV-2 antigen S1, S2, M and N protein) were 71/76 (93%) and 67/73 (92%) at 6m and 12m, respectively.”
19) Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19, Rodda, 2021 “Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.”
20) Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus Infection, Ivanova, 2021 “Performed multimodal single-cell sequencing on peripheral blood of patients with acute COVID-19 and healthy volunteers before and after receiving the SARS-CoV-2 BNT162b2 mRNA vaccine to compare the immune responses elicited by the virus and by this vaccine…both infection and vaccination induced robust innate and adaptive immune responses, our analysis revealed significant qualitative differences between the two types of immune challenges. In COVID-19 patients, immune responses were characterized by a highly augmented interferon response which was largely absent in vaccine recipients. Increased interferon signaling likely contributed to the observed dramatic upregulation of cytotoxic genes in the peripheral T cells and innate-like lymphocytes in patients but not in immunized subjects. Analysis of B and T cell receptor repertoires revealed that while the majority of clonal B and T cells in COVID-19 patients were effector cells, in vaccine recipients clonally expanded cells were primarily circulating memory cells…we observed the presence of cytotoxic CD4 T cells in COVID-19 patients that were largely absent in healthy volunteers following immunization. While hyper-activation of inflammatory responses and cytotoxic cells may contribute to immunopathology in severe illness, in mild and moderate disease, these features are indicative of protective immune responses and resolution of infection.”
21) SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans, Turner, 2021 “Bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies… durable serum antibody titres are maintained by long-lived plasma cells—non-replicating, antigen-specific plasma cells that are detected in the bone marrow long after the clearance of the antigen … S-binding BMPCs are quiescent, which suggests that they are part of a stable compartment. Consistently, circulating resting memory B cells directed against SARS-CoV-2 S were detected in the convalescent individuals. Overall, our results indicate that mild infection with SARS-CoV-2 induces robust antigen-specific, long-lived humoral immune memory in humans…overall, our data provide strong evidence that SARS-CoV-2 infection in humans robustly establishes the two arms of humoral immune memory: long-lived bone marrow plasma cells (BMPCs) and memory B-cells.”
22) SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN), Jane Hall, 2021 “The SARS-CoV-2 Immunity and Reinfection Evaluation study… 30 625 participants were enrolled into the study… a previous history of SARS-CoV-2 infection was associated with an 84% lower risk of infection, with median protective effect observed 7 months following primary infection. This time period is the minimum probable effect because seroconversions were not included. This study shows that previous infection with SARS-CoV-2 induces effective immunity to future infections in most individuals.”
23) Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers, Houlihan, 2020 “Enrolled 200 patient-facing HCWs between March 26 and April 8, 2020…represents a 13% infection rate (i.e. 14 of 112 HCWs) within the 1 month of follow-up in those with no evidence of antibodies or viral shedding at enrolment. By contrast, of 33 HCWs who tested positive by serology but tested negative by RT-PCR at enrolment, 32 remained negative by RT-PCR through follow-up, and one tested positive by RT-PCR on days 8 and 13 after enrolment.”
24) Antibodies to SARS-CoV-2 are associated with protection against reinfection, Lumley, 2021 “Critical to understand whether infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) protects from subsequent reinfection… 12219 HCWs participated…prior SARS-CoV-2 infection that generated antibody responses offered protection from reinfection for most people in the six months following infection.”
25) Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells, Cohen, 2021 “Evaluate 254 COVID-19 patients longitudinally up to 8 months and find durable broad-based immune responses. SARS-CoV-2 spike binding and neutralizing antibodies exhibit a bi-phasic decay with an extended half-life of >200 days suggesting the generation of longer-lived plasma cells… most recovered COVID-19 patients mount broad, durable immunity after infection, spike IgG+ memory B cells increase and persist post-infection, durable polyfunctional CD4 and CD8 T cells recognize distinct viral epitope regions.”
26) Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine, Sureshchandra, 2021 “Used single-cell RNA sequencing and functional assays to compare humoral and cellular responses to two doses of mRNA vaccine with responses observed in convalescent individuals with asymptomatic disease… natural infection induced expansion of larger CD8 T cell clones occupied distinct clusters, likely due to the recognition of a broader set of viral epitopes presented by the virus not seen in the mRNA vaccine.”
27) SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy, Abu-Raddad, 2021 “SARS-CoV-2 antibody-positive persons from April 16 to December 31, 2020 with a PCR-positive swab ≥14 days after the first-positive antibody test were investigated for evidence of reinfection, 43,044 antibody-positive persons who were followed for a median of 16.3 weeks…reinfection is rare in the young and international population of Qatar. Natural infection appears to elicit strong protection against reinfection with an efficacy ~95% for at least seven months.”
28) Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity, Ripperger, 2020 “Conducted a serological study to define correlates of immunity against SARS-CoV-2. Compared to those with mild coronavirus disease 2019 (COVID-19) cases, individuals with severe disease exhibited elevated virus-neutralizing titers and antibodies against the nucleocapsid (N) and the receptor binding domain (RBD) of the spike protein…neutralizing and spike-specific antibody production persists for at least 5–7 months… nucleocapsid antibodies frequently become undetectable by 5–7 months.”
29) Anti-spike antibody response to natural SARS-CoV-2 infection in the general population, Wei, 2021 “In the general population using representative data from 7,256 United Kingdom COVID-19 infection survey participants who had positive swab SARS-CoV-2 PCR tests from 26-April-2020 to 14-June-2021…we estimated antibody levels associated with protection against reinfection likely last 1.5-2 years on average, with levels associated with protection from severe infection present for several years. These estimates could inform planning for vaccination booster strategies.”
30) Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers, Lumley, 2021 “12,541 health care workers participated and had anti-spike IgG measured; 11,364 were followed up after negative antibody results and 1265 after positive results, including 88 in whom seroconversion occurred during follow-up…a total of 223 anti-spike–seronegative health care workers had a positive PCR test (1.09 per 10,000 days at risk), 100 during screening while they were asymptomatic and 123 while symptomatic, whereas 2 anti-spike–seropositive health care workers had a positive PCR test… the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.”
31) Researchers find long-lived immunity to 1918 pandemic virus, CIDRAP, 2008
and the actual 2008 NATURE journal publication by Yu
“A study of the blood of older people who survived the 1918 influenza pandemic reveals that antibodies to the strain have lasted a lifetime and can perhaps be engineered to protect future generations against similar strains…the group collected blood samples from 32 pandemic survivors aged 91 to 101..the people recruited for the study were 2 to 12 years old in 1918 and many recalled sick family members in their households, which suggests they were directly exposed to the virus, the authors report. The group found that 100% of the subjects had serum-neutralizing activity against the 1918 virus and 94% showed serologic reactivity to the 1918 hemagglutinin. The investigators generated B lymphoblastic cell lines from the peripheral blood mononuclear cells of eight subjects. Transformed cells from the blood of 7 of the 8 donors yielded secreting antibodies that bound the 1918 hemagglutinin.” Yu: “here we show that of the 32 individuals tested that were born in or before 1915, each showed sero-reactivity with the 1918 virus, nearly 90 years after the pandemic. Seven of the eight donor samples tested had circulating B cells that secreted antibodies that bound the 1918 HA. We isolated B cells from subjects and generated five monoclonal antibodies that showed potent neutralizing activity against 1918 virus from three separate donors. These antibodies also cross-reacted with the genetically similar HA of a 1930 swine H1N1 influenza strain.”
32) Live virus neutralisation testing in convalescent patients and subjects vaccinated against 19A, 20B, 20I/501Y.V1 and 20H/501Y.V2 isolates of SARS-CoV-2, Gonzalez, 2021 “No significant difference was observed between the 20B and 19A isolates for HCWs with mild COVID-19 and critical patients. However, a significant decrease in neutralisation ability was found for 20I/501Y.V1 in comparison with 19A isolate for critical patients and HCWs 6-months post infection. Concerning 20H/501Y.V2, all populations had a significant reduction in neutralising antibody titres in comparison with the 19A isolate. Interestingly, a significant difference in neutralisation capacity was observed for vaccinated HCWs between the two variants whereas it was not significant for the convalescent groups…the reduced neutralising response observed towards the 20H/501Y.V2 in comparison with the 19A and 20I/501Y.V1 isolates in fully immunized subjects with the BNT162b2 vaccine is a striking finding of the study.”
33) Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naïve and COVID-19 recovered individuals, Camara, 2021 “Characterized SARS-CoV-2 spike-specific humoral and cellular immunity in naïve and previously infected individuals during full BNT162b2 vaccination…results demonstrate that the second dose increases both the humoral and cellular immunity in naïve individuals. On the contrary, the second BNT162b2 vaccine dose results in a reduction of cellular immunity in COVID-19 recovered individuals.”
34) Op-Ed: Quit Ignoring Natural COVID Immunity, Klausner, 2021 “Epidemiologists estimate over 160 million people worldwide have recovered from COVID-19. Those who have recovered have an astonishingly low frequency of repeat infection, disease, or death.”
35) Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection, Harvey, 2021 “To evaluate evidence of SARS-CoV-2 infection based on diagnostic nucleic acid amplification test (NAAT) among patients with positive vs negative test results for antibodies in an observational descriptive cohort study of clinical laboratory and linked claims data…the cohort included 3 257 478 unique patients with an index antibody test…patients with positive antibody test results were initially more likely to have positive NAAT results, consistent with prolonged RNA shedding, but became markedly less likely to have positive NAAT results over time, suggesting that seropositivity is associated with protection from infection.”
36) SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study, Letizia, 2021 “Investigated the risk of subsequent SARS-CoV-2 infection among young adults (CHARM marine study) seropositive for a previous infection…enrolled 3249 participants, of whom 3168 (98%) continued into the 2-week quarantine period. 3076 (95%) participants…Among 189 seropositive participants, 19 (10%) had at least one positive PCR test for SARS-CoV-2 during the 6-week follow-up (1·1 cases per person-year). In contrast, 1079 (48%) of 2247 seronegative participants tested positive (6·2 cases per person-year). The incidence rate ratio was 0·18 (95% CI 0·11–0·28; p<0·001)…infected seropositive participants had viral loads that were about 10-times lower than those of infected seronegative participants (ORF1ab gene cycle threshold difference 3·95 [95% CI 1·23–6·67]; p=0·004).”
37) Associations of Vaccination and of Prior Infection With Positive PCR Test Results for SARS-CoV-2 in Airline Passengers Arriving in Qatar, Bertollini, 2021 “Of 9,180 individuals with no record of vaccination but with a record of prior infection at least 90 days before the PCR test (group 3), 7694 could be matched to individuals with no record of vaccination or prior infection (group 2), among whom PCR positivity was 1.01% (95% CI, 0.80%-1.26%) and 3.81% (95% CI, 3.39%-4.26%), respectively. The relative risk for PCR positivity was 0.22 (95% CI, 0.17-0.28) for vaccinated individuals and 0.26 (95% CI, 0.21-0.34) for individuals with prior infection compared with no record of vaccination or prior infection.”
38) Natural immunity against COVID-19 significantly reduces the risk of reinfection: findings from a cohort of sero-survey participants, Mishra, 2021 “Followed up with a subsample of our previous sero-survey participants to assess whether natural immunity against SARS-CoV-2 was associated with a reduced risk of re-infection (India)… out of the 2238 participants, 1170 were sero-positive and 1068 were sero-negative for antibody against COVID-19. Our survey found that only 3 individuals in the sero-positive group got infected with COVID-19 whereas 127 individuals reported contracting the infection the sero-negative group…from the 3 sero-positives re-infected with COVID-19, one had hospitalization, but did not require oxygen support or critical care…development of antibody following natural infection not only protects against re-infection by the virus to a great extent, but also safeguards against progression to severe COVID-19 disease.”
39) Lasting immunity found after recovery from COVID-19, NIH, 2021 “The researchers found durable immune responses in the majority of people studied. Antibodies against the spike protein of SARS-CoV-2, which the virus uses to get inside cells, were found in 98% of participants one month after symptom onset. As seen in previous studies, the number of antibodies ranged widely between individuals. But, promisingly, their levels remained fairly stable over time, declining only modestly at 6 to 8 months after infection… virus-specific B cells increased over time. People had more memory B cells six months after symptom onset than at one month afterwards… levels of T cells for the virus also remained high after infection. Six months after symptom onset, 92% of participants had CD4+ T cells that recognized the virus… 95% of the people had at least 3 out of 5 immune-system components that could recognize SARS-CoV-2 up to 8 months after infection.”
40) SARS-CoV-2 Natural Antibody Response Persists for at Least 12 Months in a Nationwide Study From the Faroe Islands, Petersen, 2021 “The seropositive rate in the convalescent individuals was above 95% at all sampling time points for both assays and remained stable over time; that is, almost all convalescent individuals developed antibodies… results show that SARS-CoV-2 antibodies persisted at least 12 months after symptom onset and maybe even longer, indicating that COVID-19-convalescent individuals may be protected from reinfection.”
41) SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells, Jung, 2021 “ex vivo assays to evaluate SARS-CoV-2-specific CD4+ and CD8+ T cell responses in COVID-19 convalescent patients up to 317 days post-symptom onset (DPSO), and find that memory T cell responses are maintained during the study period regardless of the severity of COVID-19. In particular, we observe sustained polyfunctionality and proliferation capacity of SARS-CoV-2-specific T cells. Among SARS-CoV-2-specific CD4+ and CD8+ T cells detected by activation-induced markers, the proportion of stem cell-like memory T (TSCM) cells is increased, peaking at approximately 120 DPSO.”
42) Immune Memory in Mild COVID-19 Patients and Unexposed Donors Reveals Persistent T Cell Responses After SARS-CoV-2 Infection, Ansari, 2021 “Analyzed 42 unexposed healthy donors and 28 mild COVID-19 subjects up to 5 months from the recovery for SARS-CoV-2 specific immunological memory. Using HLA class II predicted peptide megapools, we identified SARS-CoV-2 cross-reactive CD4+ T cells in around 66% of the unexposed individuals. Moreover, we found detectable immune memory in mild COVID-19 patients several months after recovery in the crucial arms of protective adaptive immunity; CD4+ T cells and B cells, with a minimal contribution from CD8+ T cells. Interestingly, the persistent immune memory in COVID-19 patients is predominantly targeted towards the Spike glycoprotein of the SARS-CoV-2. This study provides the evidence of both high magnitude pre-existing and persistent immune memory in Indian population.”
43) COVID-19 natural immunity, WHO, 2021 “Current evidence points to most individuals developing strong protective immune responses following natural infection with SARSCoV-2. Within 4 weeks following infection, 90-99% of individuals infected with the SARS-CoV-2 virus develop detectable neutralizing antibodies. The strength and duration of the immune responses to SARS-CoV-2 are not completely understood and currently available data suggests that it varies by age and the severity of symptoms. Available scientific data suggests that in most people immune responses remain robust and protective against reinfection for at least 6-8 months after infection (the longest follow up with strong scientific evidence is currently approximately 8 months).”
44) Antibody Evolution after SARS-CoV-2 mRNA Vaccination, Cho, 2021 “We conclude that memory antibodies selected over time by natural infection have greater potency and breadth than antibodies elicited by vaccination…boosting vaccinated individuals with currently available mRNA vaccines would produce a quantitative increase in plasma neutralizing activity but not the qualitative advantage against variants obtained by vaccinating convalescent individuals.”
45) Humoral Immune Response to SARS-CoV-2 in IcelandGudbjartsson, 2020 “Measured antibodies in serum samples from 30,576 persons in Iceland…of the 1797 persons who had recovered from SARS-CoV-2 infection, 1107 of the 1215 who were tested (91.1%) were seropositive…results indicate risk of death from infection was 0.3% and that antiviral antibodies against SARS-CoV-2 did not decline within 4 months after diagnosis (para).”
46)  Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection, Dan, 2021 “Analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection…IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset.”
47) The prevalence of adaptive immunity to COVID-19 and reinfection after recovery – a comprehensive systematic review and meta-analysis of 12 011 447 individuals, Chivese, 2021 “Fifty-four studies, from 18 countries, with a total of 12 011 447 individuals, followed up to 8 months after recovery, were included. At 6-8 months after recovery, the prevalence of detectable SARS-CoV-2 specific immunological memory remained high; IgG – 90.4%… pooled prevalence of reinfection was 0.2% (95%CI 0.0 – 0.7, I2 = 98.8, 9 studies). Individuals who recovered from COVID-19 had an 81% reduction in odds of a reinfection (OR 0.19, 95% CI 0.1 – 0.3, I2 = 90.5%, 5 studies).”
48) Reinfection Rates among Patients who Previously Tested Positive for COVID-19: a Retrospective Cohort Study, Sheehan, 2021 “Retrospective cohort study of one multi-hospital health system included 150,325 patients tested for COVID-19 infection…prior infection in patients with COVID-19 was highly protective against reinfection and symptomatic disease. This protection increased over time, suggesting that viral shedding or ongoing immune response may persist beyond 90 days and may not represent true reinfection.”
49) Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy, Vitale, 2020 “The study results suggest that reinfections are rare events and patients who have recovered from COVID-19 have a lower risk of reinfection. Natural immunity to SARS-CoV-2 appears to confer a protective effect for at least a year, which is similar to the protection reported in recent vaccine studies.”
50) Prior SARS-CoV-2 infection is associated with protection against symptomatic reinfection, Hanrath, 2021 “We observed no symptomatic reinfections in a cohort of healthcare workers…this apparent immunity to re-infection was maintained for at least 6 months…test positivity rates were 0% (0/128 [95% CI: 0–2.9]) in those with previous infection compared to 13.7% (290/2115 [95% CI: 12.3–15.2]) in those without (P<0.0001 χ2 test).”
51) mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status, Neidleman, 2021 “In infection-naïve individuals, the second dose boosted the quantity and altered the phenotypic properties of SARS-CoV-2-specific T cells, while in convalescents the second dose changed neither. Spike-specific T cells from convalescent vaccinees differed strikingly from those of infection-naïve vaccinees, with phenotypic features suggesting superior long-term persistence and ability to home to the respiratory tract including the nasopharynx.”
52) Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals, Grifoni, 2020 “Using HLA class I and II predicted peptide “megapools,” circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, spike, and N proteins each accounted for 11%–27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a, and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted.”
53) NIH Director’s Blog: Immune T Cells May Offer Lasting Protection Against COVID-19, Collins, 2021 “Much of the study on the immune response to SARS-CoV-2, the novel coronavirus that causes COVID-19, has focused on the production of antibodies. But, in fact, immune cells known as memory T cells also play an important role in the ability of our immune systems to protect us against many viral infections, including—it now appears—COVID-19.An intriguing new study of these memory T cells suggests they might protect some people newly infected with SARS-CoV-2 by remembering past encounters with other human coronaviruses. This might potentially explain why some people seem to fend off the virus and may be less susceptible to becoming severely ill with COVID-19.”
54) Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants, Wang, 2021 “Our study demonstrates that convalescent subjects previously infected with ancestral variant SARS-CoV-2 produce antibodies that cross-neutralize emerging VOCs with high potency…potent against 23 variants, including variants of concern.”
55) Why COVID-19 Vaccines Should Not Be Required for All Americans, Makary, 2021 “Requiring the vaccine in people who are already immune with natural immunity has no scientific support. While vaccinating those people may be beneficial – and it’s a reasonable hypothesis that vaccination may bolster the longevity of their immunity – to argue dogmatically that they must get vaccinated has zero clinical outcome data to back it. As a matter of fact, we have data to the contrary: A Cleveland Clinic study found that vaccinating people with natural immunity did not add to their level of protection.”
56) Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence, Ma, 2021 “Screened 21 well-characterized, longitudinally-sampled convalescent donors that recovered from mild COVID-19…following a typical case of mild COVID-19, SARS-CoV-2-specific CD8+ T cells not only persist but continuously differentiate in a coordinated fashion well into convalescence, into a state characteristic of long-lived, self-renewing memory.”
57) Decrease in Measles Virus-Specific CD4 T Cell Memory in Vaccinated Subjects, Naniche, 2004 “Characterized the profiles of measles vaccine (MV) vaccine-induced antigen-specific T cells over time since vaccination. In a cross-sectional study of healthy subjects with a history of MV vaccination, we found that MV-specific CD4 and CD8 T cells could be detected up to 34 years after vaccination. The levels of MV-specific CD8 T cells and MV-specific IgG remained stable, whereas the level of MV-specific CD4 T cells decreased significantly in subjects who had been vaccinated >21 years earlier.”
58) Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination, Palm, 2019 “The success of vaccines is dependent on the generation and maintenance of immunological memory. The immune system can remember previously encountered pathogens, and memory B and T cells are critical in secondary responses to infection. Studies in mice have helped to understand how different memory B cell populations are generated following antigen exposure and how affinity for the antigen is determinant to B cell fate… upon re-exposure to an antigen the memory recall response will be faster, stronger, and more specific than a naïve response. Protective memory depends first on circulating antibodies secreted by LLPCs. When these are not sufficient for immediate pathogen neutralization and elimination, memory B cells are recalled.”
59) SARS-CoV-2 specific memory B-cells from individuals with diverse disease severities recognize SARS-CoV-2 variants of concern, Lyski, 2021 “Examined the magnitude, breadth, and durability of SARS-CoV-2 specific antibodies in two distinct B-cell compartments: long-lived plasma cell-derived antibodies in the plasma, and peripheral memory B-cells along with their associated antibody profiles elicited after in vitro stimulation. We found that magnitude varied amongst individuals, but was the highest in hospitalized subjects. Variants of concern (VoC) -RBD-reactive antibodies were found in the plasma of 72% of samples in this investigation, and VoC-RBD-reactive memory B-cells were found in all but 1 subject at a single time-point. This finding, that VoC-RBD-reactive MBCs are present in the peripheral blood of all subjects including those that experienced asymptomatic or mild disease, provides a reason for optimism regarding the capacity of vaccination, prior infection, and/or both, to limit disease severity and transmission of variants of concern as they continue to arise and circulate.”
60) Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection, Wang, 2021 “T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in virus-exposed individuals…report virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts…close contacts are able to gain T-cell immunity against SARS-CoV-2 despite lacking a detectable infection.”
61) CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants, Redd, 2021and Lee, 2021 “The CD4 and CD8 responses generated after natural infection are equally robust, showing activity against multiple “epitopes” (little segments) of the spike protein of the virus. For instance, CD8 cells responds to 52 epitopes and CD4 cells respond to 57 epitopes across the spike protein, so that a few mutations in the variants cannot knock out such a robust and in-breadth T cell response…only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.”
62) Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2,La Jolla, Crotty and Sette, 2020 “Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2”
63) Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans, Mateus, 2020 “Found that the pre-existing reactivity against SARS-CoV-2 comes from memory T cells and that cross-reactive T cells can specifically recognize a SARS-CoV-2 epitope as well as the homologous epitope from a common cold coronavirus. These findings underline the importance of determining the impacts of pre-existing immune memory in COVID-19 disease severity.”
64) Longitudinal observation of antibody responses for 14 months after SARS-CoV-2 infectionDehgani-Mobaraki, 2021 “Better understanding of antibody responses against SARS-CoV-2 after natural infection might provide valuable insights into the future implementation of vaccination policies. Longitudinal analysis of IgG antibody titers was carried out in 32 recovered COVID-19 patients based in the Umbria region of Italy for 14 months after Mild and Moderately-Severe infection…study findings are consistent with recent studies reporting antibody persistency suggesting that induced SARS-CoV-2 immunity through natural infection, might be very efficacious against re-infection (>90%) and could persist for more than six months. Our study followed up patients up to 14 months demonstrating the presence of anti-S-RBD IgG in 96.8% of recovered COVID-19 subjects.”
65) Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19, Juno, 2020 “Characterized humoral and circulating follicular helper T cell (cTFH) immunity against spike in recovered patients with coronavirus disease 2019 (COVID-19). We found that S-specific antibodies, memory B cells and cTFH are consistently elicited after SARS-CoV-2 infection, demarking robust humoral immunity and positively associated with plasma neutralizing activity.”
66) Convergent antibody responses to SARS-CoV-2 in convalescent individuals, Robbiani, 2020 “149 COVID-19-convalescent individuals…antibody sequencing revealed the expansion of clones of RBD-specific memory B cells that expressed closely related antibodies in different individuals. Despite low plasma titres, antibodies to three distinct epitopes on the RBD neutralized the virus with half-maximal inhibitory concentrations (IC50 values) as low as 2 ng ml−1.”
67) Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence, Hartley, 2020 “COVID-19 patients rapidly generate B cell memory to both the spike and nucleocapsid antigens following SARS-CoV-2 infection…RBD- and NCP-specific IgG and Bmem cells were detected in all 25 patients with a history of COVID-19.”
68) Had COVID? You’ll probably make antibodies for a lifetime, Callaway, 2021 “People who recover from mild COVID-19 have bone-marrow cells that can churn out antibodies for decades…the study provides evidence that immunity triggered by SARS-CoV-2 infection will be extraordinarily long-lasting.”
69) A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2, Majdoubi, 2021 In greater Vancouver Canada, “using a highly sensitive multiplex assay and positive/negative thresholds established in infants in whom maternal antibodies have waned, we determined that more than 90% of uninfected adults showed antibody reactivity against the spike protein, receptor-binding domain (RBD), N-terminal domain (NTD), or the nucleocapsid (N) protein from SARS-CoV-2.”
70) SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19, Braun, 2020 “The results indicate that spike-protein cross-reactive T cells are present, which were probably generated during previous encounters with endemic coronaviruses.”
71) Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection, Wang, 2021 “A cohort of 63 individuals who have recovered from COVID-19 assessed at 1.3, 6.2 and 12 months after SARS-CoV-2 infection…the data suggest that immunity in convalescent individuals will be very long lasting.”
72) One Year after Mild COVID-19: The Majority of Patients Maintain Specific Immunity, But One in Four Still Suffer from Long-Term Symptoms, Rank, 2021 “Long-lasting immunological memory against SARS-CoV-2 after mild COVID-19.”
73) IDSA, 2021 “Immune responses to SARS-CoV-2 following natural infection can persist for at least 11 months… natural infection (as determined by a prior positive antibody or PCR-test result) can confer protection against SARS-CoV-2 infection.”
74) Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study, Holm Hansen, 2021 Denmark, “during the first surge (ie, before June, 2020), 533 381 people were tested, of whom 11 727 (2·20%) were PCR positive, and 525 339 were eligible for follow-up in the second surge, of whom 11 068 (2·11%) had tested positive during the first surge. Among eligible PCR-positive individuals from the first surge of the epidemic, 72 (0·65% [95% CI 0·51–0·82]) tested positive again during the second surge compared with 16 819 (3·27% [3·22–3·32]) of 514 271 who tested negative during the first surge (adjusted RR 0·195 [95% CI 0·155–0·246]).”
75) Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity, Moderbacher, 2020 “Adaptive immune responses limit COVID-19 disease severity…multiple coordinated arms of adaptive immunity control better than partial responses…completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4+ and CD8+ T cells were each associated with milder disease. Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4+ and CD8+ T cells in protective immunity in COVID-19.”
76) Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals, Ni, 2020 “Collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells.”
77) Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection, Zuo, 2020 “Analysed the magnitude and phenotype of the SARS-CoV-2 cellular immune response in 100 donors at six months following primary infection and related this to the profile of antibody level against spike, nucleoprotein and RBD over the previous six months. T-cell immune responses to SARS-CoV-2 were present by ELISPOT and/or ICS analysis in all donors and are characterised by predominant CD4+ T cell responses with strong IL-2 cytokine expression… functional SARS-CoV-2-specific T-cell responses are retained at six months following infection.”
78) Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees, Tarke, 2021 “Performed a comprehensive analysis of SARS-CoV-2-specific CD4+ and CD8+ T cell responses from COVID-19 convalescent subjects recognizing the ancestral strain, compared to variant lineages B.1.1.7, B.1.351, P.1, and CAL.20C as well as recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines… the sequences of the vast majority of SARS-CoV-2 T cell epitopes are not affected by the mutations found in the variants analyzed. Overall, the results demonstrate that CD4+ and CD8+ T cell responses in convalescent COVID-19 subjects or COVID-19 mRNA vaccinees are not substantially affected by mutations.”
79) A 1 to 1000 SARS-CoV-2 reinfection proportion in members of a large healthcare provider in Israel: a preliminary report, Perez, 2021 Israel, “out of 149,735 individuals with a documented positive PCR test between March 2020 and January 2021, 154 had two positive PCR tests at least 100 days apart, reflecting a reinfection proportion of 1 per 1000.”
80) Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients, Iyer, 2020 “Measured plasma and/or serum antibody responses to the receptor-binding domain (RBD) of the spike (S) protein of SARS-CoV-2 in 343 North American patients infected with SARS-CoV-2 (of which 93% required hospitalization) up to 122 days after symptom onset and compared them to responses in 1548 individuals whose blood samples were obtained prior to the pandemic…IgG antibodies persisted at detectable levels in patients beyond 90 days after symptom onset, and seroreversion was only observed in a small percentage of individuals. The concentration of these anti-RBD IgG antibodies was also highly correlated with pseudovirus NAb titers, which also demonstrated minimal decay. The observation that IgG and neutralizing antibody responses persist is encouraging, and suggests the development of robust systemic immune memory in individuals with severe infection.”
81) A population-based analysis of the longevity of SARS-CoV-2 antibody seropositivity in the United States, Alfego, 2021 “To track population-based SARS-CoV-2 antibody seropositivity duration across the United States using observational data from a national clinical laboratory registry of patients tested by nucleic acid amplification (NAAT) and serologic assays… specimens from 39,086 individuals with confirmed positive COVID-19…both S and N SARS-CoV-2 antibody results offer an encouraging view of how long humans may have protective antibodies against COVID-19, with curve smoothing showing population seropositivity reaching 90% within three weeks, regardless of whether the assay detects N or S-antibodies. Most importantly, this level of seropositivity was sustained with little decay through ten months after initial positive PCR.”
82) What are the roles of antibodies versus a durable, high- quality T-cell response in protective immunity against SARS-CoV-2? Hellerstein, 2020 “Progress in laboratory markers for SARS-CoV2 has been made with identification of epitopes on CD4 and CD8 T-cells in convalescent blood. These are much less dominated by spike protein than in previous coronavirus infections. Although most vaccine candidates are focusing on spike protein as antigen, natural infection by SARS-CoV-2 induces broad epitope coverage, cross-reactive with other betacoronviruses.”
83) Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients, Peng, 2020 “Study of 42 patients following recovery from COVID-19, including 28 mild and 14 severe cases, comparing their T cell responses to those of 16 control donors…found the breadth, magnitude and frequency of memory T cell responses from COVID-19 were significantly higher in severe compared to mild COVID-19 cases, and this effect was most marked in response to spike, membrane, and ORF3a proteins…total and spike-specific T cell responses correlated with the anti-Spike, anti-Receptor Binding Domain (RBD) as well as anti-Nucleoprotein (NP) endpoint antibody titre…furthermore showed a higher ratio of SARS-CoV-2-specific
CD8+ to CD4+ T cell responses…immunodominant epitope clusters and peptides containing T cell epitopes identified in this study will provide critical tools to study the role of virus-specific T cells in control and resolution of SARS-CoV-2 infections.”
84) Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19, Sekine, 2020 “SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19…mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19…collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.”
85) Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients, Lafron, 2021 “Provide a full picture of cellular and humoral immune responses of COVID-19 patients and prove that robust polyfunctional CD8+ T cell responses concomitant with low anaphylatoxin levels correlate with mild infections.”
86) SARS-CoV-2 T-cell epitopes define heterologous and COVID-19 induced T-cell recognition, Nelde, 2020 “The first work identifying and characterizing SARS-CoV-2-specific and cross-reactive HLA class I and HLA-DR T-cell epitopes in SARS-CoV-2 convalescents (n = 180) as well as unexposed individuals (n = 185) and confirming their relevance for immunity and COVID-19 disease course…cross-reactive SARS-CoV-2 T-cell epitopes revealed pre-existing T-cell responses in 81% of unexposed individuals, and validation of similarity to common cold human coronaviruses provided a functional basis for postulated heterologous immunity in SARS-CoV-2 infection…intensity of T-cell responses and recognition rate of T-cell epitopes was significantly higher in the convalescent donors compared to unexposed individuals, suggesting that not only expansion, but also diversity spread of SARS-CoV-2 T-cell responses occur upon active infection.”
87) Karl Friston: up to 80% not even susceptible to Covid-19, Sayers, 2020 “Results have just been published of a study suggesting that 40%-60% of people who have not been exposed to coronavirus have resistance at the T-cell level from other similar coronaviruses like the common cold…the true portion of people who are not even susceptible to Covid-19 may be as high as 80%.”
88) CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses, Lineburg, 2021 “Screening of SARS-CoV-2 peptide pools revealed that the nucleocapsid (N) protein induced an immunodominant response in HLA-B7+ COVID-19-recovered individuals that was also detectable in unexposed donors…the basis of selective T cell cross-reactivity for an immunodominant SARS-CoV-2 epitope and its homologs from seasonal coronaviruses, suggesting long-lasting protective immunity.”
89) SARS-CoV-2 genome-wide mapping of CD8 T cell recognition reveals strong immunodominance and substantial CD8 T cell activation in COVID-19 patients, Saini, 2020 “COVID-19 patients showed strong T cell responses, with up to 25% of all CD8+ lymphocytes specific to SARS-CoV-2-derived immunodominant epitopes, derived from ORF1 (open reading frame 1), ORF3, and Nucleocapsid (N) protein. A strong signature of T cell activation was observed in COVID-19 patients, while no T cell activation was seen in the ‘non-exposed’ and ‘high exposure risk’ healthy donors.”
90) Equivalency of Protection from Natural Immunity in COVID-19 Recovered Versus Fully Vaccinated Persons: A Systematic Review and Pooled Analysis, Shenai, 2021 “Systematic review and pooled analysis of clinical studies to date, that (1) specifically compare the protection of natural immunity in the COVID-recovered versus the efficacy of full vaccination in the COVID-naive, and (2) the added benefit of vaccination in the COVID-recovered, for prevention of subsequent SARS-CoV-2 infection…review demonstrates that natural immunity in COVID-recovered individuals is, at least, equivalent to the protection afforded by full vaccination of COVID-naïve populations. There is a modest and incremental relative benefit to vaccination in COVID-recovered individuals; however, the net benefit is marginal on an absolute basis.”
91) ChAdOx1nCoV-19 effectiveness during an unprecedented surge in SARS CoV-2 infections, Satwik, 2021 “The third key finding is that previous infections with SARS-CoV-2 were significantly protective against all studied outcomes, with an effectiveness of 93% (87 to 96%) seen against symptomatic infections, 89% (57 to 97%) against moderate to severe disease and 85% (-9 to 98%) against supplemental oxygen therapy. All deaths occurred in previously uninfected individuals. This was higher protection than that offered by single or double dose vaccine.”

Author

  • Dr. Alexander holds a PhD. He has experience in epidemiology and in the teaching of clinical epidemiology, evidence-based medicine, and research methodology. Dr Alexander is a former Assistant Professor at McMaster University in evidence-based medicine and research methods; former COVID Pandemic evidence-synthesis consultant advisor to WHO-PAHO Washington, DC (2020) and former senior advisor to COVID Pandemic policy in Health and Human Services (HHS) Washington, DC (A Secretary), US government; worked/appointed in 2008 at WHO as a regional specialist/epidemiologist in Europe’s Regional office Denmark, worked for the government of Canada as an epidemiologist for 12 years, appointed as the Canadian in-field epidemiologist (2002-2004) as part of an international CIDA funded, Health Canada executed project on TB/HIV co-infection and MDR-TB control (involving India, Pakistan, Nepal, Sri Lanka, Bangladesh, Bhutan, Maldives, Afghanistan, posted to Kathmandu); employed from 2017 to 2019 at Infectious Diseases Society of America (IDSA) Virginia USA as the evidence synthesis meta-analysis systematic review guideline development trainer; currently a COVID-19 consultant researcher in the US-C19 research group

Kaiser Permanente’s Antioch Mental Health Services celebrates 10 years at Hillcrest location

Tuesday, October 26th, 2021

Th building at 3454 Hillcrest Avenue which houses the Antioch location for Kaiser Permanente’s Department of Mental Health and Addiction Medicine.  Source: Kaiser

By Antonia Ehlers, PR and Media Relations, Kaiser Permanente Northern California

Kaiser Permanente’s Department of Mental Health and Addiction Medicine at their location on Hillcrest in Antioch is currently celebrating its 10th year of service. Mental health services are more important than ever, especially since the COVID-19 pandemic.

“We’ve definitely noticed an uptick in patients accessing our services,” said Director of Addiction Medicine Curtis Arthur, MFT. “Everybody is dealing with increased stress. People often turn to various substances to deal with that stress. It’s so important to engage in care during this very difficult time.”

It can be scary and intimidating to ask for help. However, Arthur and his team assure people of this: They meet people of all ages where they are, without judgment.

“Treatment for addiction can range from educational therapy to intensive therapy,” Arthur noted. “We know that the disease of addiction affects not only individuals, but also the family members who care about that person. We educate those family members and connect them to others who are affected in the same way.”

During the past year and a half, virtual appointments have significantly increased.

“Virtual care has made things so much more accessible,” Arthur said. “We are offering the latest technology and expertise, so patients can choose how and when they want to access their care.”

One of the key advances in recent years is the ability to diagnose various mental health conditions earlier and more accurately. According to the Director of Mental Health at Kaiser Permanente Antioch, Natasha Quackenbush, Psy.D , the demand for mental health services continues to grow, year after year.

“We’re encouraged that more and more people are reaching out for help, particularly because of the COVID-19 pandemic,” she said. “We’re also seeing more people from various community groups – particularly African American, Asian and Latino communities – reach out for help.”

Every person’s needs are unique and every Kaiser Permanente member who seeks support receives a care plan tailored to their mental and physical needs, drawing on a range of available services. A patient’s individual treatment could include outpatient psychiatric services, individual therapy, group programs, medication management, crisis intervention, intensive outpatient programs, and inpatient psychiatric care.

“It’s wonderful that as a society today, we are making progress to destigmatize mental health issues,” Quackenbush added. “They are, in fact, medical conditions. We don’t judge, because it would be the same as judging someone who has cancer or diabetes. There is hope. Mental health conditions can be treated, and our dedicated clinicians genuinely want to make a difference in our patients’ lives.”

For more information about Kaiser Permanente Mental Health Services, visit www.kp.org/mentalhealth

Contra Costa Supervisor Burgis recovering after successful pacemaker implant

Saturday, October 23rd, 2021

Second surgery in past three years to address heart defect since birth

By Mark Goodwin, Chief of Staff, Supervisor Diane Burgis

Supervisor Diane Burgis. Herald file photo.

Contra Costa County Board of Supervisors Chair Diane Burgis is recovering at home following successful surgery to implant a pacemaker as a precaution to help steady an irregular heartbeat. Doctors discovered the irregular heartbeat during a series of routine preventative medical visits.

In a post on her Facebook page on Friday, Burgis, who remarried earlier this year, wrote, “All is good! Had a pacemaker put in this week. I am home recovering. Thanks for all the well wishes.”

The surgery went very smoothly, and while she will need to take it easy for a few weeks during recovery, she will not skip a beat in fulfilling the duties of her office. The residents of Contra Costa County, particularly those in District 3, will continue to receive the same high level of service, sound decision-making, and representation they depend on and deserve.

Since birth, Supervisor Burgis has been living with a congenital heart defect and was diagnosed with aortic stenosis, a narrowing of the aortic valve, and had a successful valve replacement surgery in February 2019.

She thanks the medical team at Kaiser Medical Center in Walnut Creek and her physicians for their care and encourages everyone to keep up with their regular medical visits, especially during the continuing COVID-19 pandemic.

“If I hadn’t gone in for my routine preventative appointments, I wouldn’t have known that my heart was not doing its job to its full capacity,” Burgis observed. “Throughout the COVID-19 pandemic, I have been encouraging people to keep up with their regular exams and tests rather than waiting to get medical care. I’m glad that I followed my advice.”

Cards and well wishes may be sent to the supervisor at her main office, 3361 Walnut Blvd., Suite 140, Brentwood, CA 94513.

Burgis represents District 3, the largest of the five Contra Costa County Board of Supervisor districts, including Bethel Island, Brentwood, Byron, Discovery Bay, Knightsen, Oakley and parts of Antioch in Eastern Contra Costa County, and Blackhawk, Diablo, and Tassajara Valley in the San Ramon Valley portion of the district.

Allen Payton contributed to this report.

Antioch hires social justice organization to develop non-emergency crisis response system, survey residents

Monday, October 18th, 2021

Expertise is in data gathering, but no experience developing a program; recruiting workers at $20 per hour for survey; focus is on people of color and impoverished residents

By Allen Payton

During the August 10th Antioch City Council meeting Urban Strategies Council (USC), a-not-for-profit social justice organization, was introduced and hired to design a mobile, mental health crisis intervention model for the City of Antioch, to address non-emergency calls using well-trained community respondents. Urban Strategies Council presentation ACC081021

According to city staff, some calls to 911 and the City’s non-emergency number are for situations that do not need a police officer to respond. To develop Antioch’s program public feedback is needed. USC is collecting input from Antioch residents who have experience with the 911 system or feedback on how the City addresses non-emergency 911 calls and community needs. This survey aims to understand community needs from the voice of the people most impacted.

According to USC’s presentation to the city council, the community resident survey is “focusing on most impacted residents – African-American, Asian-Pacific Islander, Latinx (Latino/Hispanic).” The presentation also shows they plan to have a pilot program developed by the end of this month.

According to Assistant City Manager Rosanna Bayon Moore, “USC is in the process of outreach for the City’s program design phase.  A survey is one of the many ways they are collecting information to inform the program design.”

USC has been recruiting workers to help with the survey, offering to pay $20 per hour this past week and next. One was sent to all staff at Antioch High School, according to Jon Davis who works for the school district.

According to their website, USC is “a regional research and advocacy organization dedicated to social, economic, and racial equity. We work to hold institutions and systems accountable to community needs.” Their “mission is to eliminate persistent poverty in the Bay Area by working with partners to transform low-income neighborhoods into vibrant, healthy communities.”

Their work focuses on the issue areas of Criminal Justice Reform, Boys and Men of Color, Economic Opportunity, Pathways to Career and College, and Violence Prevention. Regarding USC’s approach, they write, “In order to move the needle on persistent poverty, we need to change the systems that are currently ineffective, and so we focus  on reforming the systems that serve low-income communities.”

Asked why the organization was chosen and what experience they have in developing a non-emergency response system for a city, what does their mission have to do with developing a non-emergency response system, who suggested USC as the organization to hire for this, a staff or council member, and how much the City is paying them to develop the program and do the survey.

Bayon Moore responded Saturday evening with the following: “The City seeks to establish an effective mobile crisis intervention response program.  This initiative is supported by the entire City Council.  Staff’s work in this area is a high priority which is why the program is being overseen by the City Manager’s Office.

Multicultural literacy is a centerpiece of our approach to program design that cannot be ignored or minimized in terms of importance.  This includes but is not limited to being aware and mindful of all resident needs, including our neighbors who may not participate in conventional public processes.

Urban Strategies Council was selected by a multi department interview process that included PD.  The engagement threshold is within the City Manager’s signature authority.

I suggest you take a closer look at USC’s professional skills and capabilities.  The August presentation I’ve already shared includes a link to materials that describe their prior work and Antioch’s actual scope of work, again, including but not limited to a survey.”

In response, some questions were repeated, and further questions were asked of Bayon Moore late Saturday night, including “how much is the contract for with USC? If they do have any experience developing a non-emergency response program/mobile, mental health crisis intervention model, can you please provide that information or point to where it can be found on their website? What does their mission have to do with developing a non-emergency response system? Why is this focused on people of color and impoverished residents? Is the effort of the survey and entire response program focused on them as is USC’s mission and focus areas? Also, how does USC know, as it shows in the presentation to Council on Aug. 10th, without first surveying Antioch residents, that ‘African-American, Asian-Pacific Islander, Latinx’ are the ‘most impacted residents’ of our city? Do they have some previously gathered data to support that claim? Were any other organizations considered for the project that might have more or any experience developing and implementing one in a city? Finally, without having to take the survey, can you please provide a list of the questions they’re asking?”

Questions were also sent Saturday afternoon to David Harris, President and CEO of USC, asking what experience they have in developing a non-emergency response system for cities and how would a system in Antioch fulfill his organization’s mission. He was also asked, without first surveying Antioch residents, how can he claim, as it shows in his presentation, that “African-American, Asian-Pacific Islander, Latinx” are the “most impacted residents” of our city, and does he have some previously gathered data to support that claim. Finally, Harris was asked if it was one of the city staff or council members who contacted him for the presentation and contract with the city, and if he was still recruiting workers for this next week. He did not respond before publication time, early Monday afternoon.

Harris called late Monday afternoon and agreed to call back later that evening following his organization’s board meeting, or the next day, but did not.

The survey is anonymous and confidential and takes seven minutes to complete.

English/Inglés: https://www.surveymonkey.com/r/Antioch_2021

Spanish/Español: https://www.surveymonkey.com/r/Antioch_Spanish

Please check back later for any updates to this report.

Contra Costa to lift masking requirements in some indoor settings on Nov. 1 

Thursday, October 14th, 2021

Won’t lift all mask requirements until county reaches 80% fully vaccinated which includes kids ages 5-11 who aren’t yet eligible for vaccinations; figure also includes those under age 5

“This will allow vaccinated people to FEEL safe removing their masks” – Contra Costa County Health Officer Dr. Chris Farnitano (emphasis added)

By Contra Costa County Health Services

With COVID-19 cases and hospitalizations declining, Contra Costa County will lift masking requirements on Nov. 1 in certain indoor settings where everyone is fully vaccinated

Eligible settings are in controlled spaces not open to the general public, including offices, gyms and fitness centers, employee commuter vehicles, indoor college classes and organized gatherings in any other indoor setting, such as a religious gathering.

Under the order, participating businesses, organizations and hosts must verify that all patrons, employees and attendees are fully vaccinated before allowing people inside their facilities not to wear face coverings. There can be no more than 100 persons present at these facilities, and the group of those present must gather on a regular basis. Those present should also not have COVID-19 symptoms.

“This will allow vaccinated people to feel safe removing their masks at the office and when they’re working out at the gym,” said Dr. Chris Farnitano, health officer for Contra Costa County. “Of course, people in these places can keep wearing masks if that makes them feel more comfortable.”

Indoor-masking requirements would remain in effect for the time-being in public settings, such as bars, restaurants and retail stores until other targets are met. Masking would also still be required in indoor K-12 school settings.

San Francisco and Marin County recently issued similar orders easing masking requirements as COVID cases and hospitalizations have steadily declined since their peaks in the summer. In Contra Costa County, COVID-related hospitalizations are down to 69 from a summer high of 227 in August. Case rates in the county have seen a similar decline over the past two months.

Cases and hospitalizations spiked in the summer after the state relaxed restrictions and the highly contagious Delta variant swept through the country.

Dr. Farnitano said masking requirements had to be reinstated in the summer to blunt the impact of the Delta surge and keep hospitals from being overwhelmed. With the surge receding, Dr. Farnitano said it makes sense now to lift mask requirements in non-public places like offices and gyms for vaccinated people, who are less likely to get infected with COVID or transmit the virus.

“We’re in a safer place than we were two months ago,” Dr. Farnitano said. “My hope is that two months from now vaccinated people won’t have to wear masks in other places like restaurants, bars and retail stores. The way we get there is for those who remain unvaccinated to get immunized.”

The County will lift its indoor masking requirements for restaurants, bars and retails stores when certain criteria are met, including when 80% of residents are fully vaccinated. As of Thursday, 71.6% of all county residents were fully vaccinated.

CCC Vaccination Percentage as of 10:30 AM on Oct. 14, 2021. Source: Contra Costa Health Services COVID Vaccine Dashboard

Discrepancy in Fully Vaccinated Percentages Clarified

That 71.6% figure differs significantly from what is on the county’s COVID Vaccine Dashboard, which shows 82.5% of residents over age 12 are fully vaccinated, as of today, Oct. 14, 2021 at 11:30 a.m.

Health Services staff was asked, “which is the correct figure, the 82.5% as it shows on your Vaccine Dashboard, or 71.6%? Why the difference?”

Health Services spokesman Karl Fischer responded, “Both are actually correct. The higher percentage, found on our vaccination dashboard, refers to county residents who are vaccinated, and who are also 12 and older. (Younger people are not yet able to get vaccinate).

The other percentage, which we display on the front page, is our percentage of all county residents who are vaccinated, including those younger children who are not yet eligible for vaccine. We began displaying this metric last week, after we announced the criteria for lifting the county’s face covering requirement, because the percentage of the total population that is vaccinated is part of that criteria.”

The 80% requirement applies to the county’s total population, including all of those under age 12, both those ages 5-11 not yet eligible for vaccination as well as those under age 5. According to Fischer, the county uses California Department of Finance projections rather than the 2020 Census Data. Asked why, Fischer said he had to research that.

The statistic showing the percentage of total population fully vaccinated is not currently included on the county’s COVID Vaccine Dashboard. Fischer said he’d look into it and that it might already be in the works to add it.

Please check back later for any updates to this report.

Allen Payton contributed to this report.

 

In spite of opposition Contra Costa Supervisors approve COVID-19 vaccine anti-misinformation resolution

Wednesday, October 13th, 2021

“The Board…declares that COVID-19 health misinformation is an urgent public health crisis” – from resolution

“You are spreading misinformation that the vaccine is the be all and end all…” – county resident Carolyn Stream

“We are going to be as loud as we can be and as visible as we can be to put out information that is correct…” – Supervisor John Gioia

County might enter the less health restrictive yellow ranking by the end of October, currently has less than 75 COVID-19 patients hospitalized in county hospitals. – Contra Costa Health Officer, Dr. Chris Farnitano

Discuss $110 million Measure X half-cent sales tax revenue wish list

By Daniel Borsuk

The Contra Costa County Board of Supervisors, on a 5-0 vote, approved a resolution aimed at turning around rising public skepticism against the COVID-19 vaccines during their regular, weekly meeting on Tuesday. It is entitled “Declaring COVID-19 Misinformation as a Public Health Crisis”. (See resolution and below)

Supervisors listened to 50 speakers, mostly opposed to the resolution that “declares COVID-19 health misinformation is an urgent public health crisis affecting our entire community and the County of Contra Costa commits to combating health misinformation is an urgent public health crisis affecting our entire community and County of Contra Costa commits to combating health misinformation and curbing the spread of falsehoods that threaten the health and safety of our residents.”

“We are going to be as loud as we can be and as visible as we can be to put out information that is correct, science-based and corrects the general misinformation that’s out there,” resolution-co-author District 1 Supervisor John Gioia said.

“We are not making any judgement against anyone,” said co-author Supervisor Karen Mitchoff of Pleasant Hill. “We’re not infringing on anyone’s free speech rights.  This is not the case.  We are calling out the misinformation that leads some to not be vaccinated.”

One message in the resolution states: “The Board of Supervisors and County of Contra Costa is troubled by and actively discourages the spread of COVID-19 misinformation as it is a dangerous threat to public health.”

“There are ae people who don’t believe in public officials,” said District 2 Supervisor Candace Andersen of Danville. “I will support this resolution because it conveys prudent decisions based on scientifically based information.”

District 5 Supervisor Federal Glover went right to the point. “Get your shot and protect yourself and your loved ones.”

But supervisors got an earful of criticism from the 50 speakers who viewed the supervisors’ resolution as a move in the wrong direction, a direction towards infringements of freedom of speech, “freedom of medical choice,” and “freedom of medical information.”

One such speaker, Lucy Busto of Oakley bristled at the supervisors for considering a resolution that would “infringe on our medical freedom of choice.”  She said, “We have no idea what the long-term effects of these vaccines are.”

“You are spreading misinformation that the vaccine is the be all and end all when there are many unanswered questions about the vaccine,” said another speaker, Carolyn Stream.

But retired nurse Mary Schreiber urged supervisors to adopt the resolution saying, “This is really supported by our health care professionals.”

Contra Costa County Health Officer Dr. Chris Farnitano, who also reported the county might enter the less health restrictive yellow ranking by the end of October, currently has less than 75 COVID-19 patients hospitalized in county hospitals.

“You are infringing on our rights to medical information,” said Lucy Busto of Oakley. “We have no idea what the long-term effects of these vaccines are”

“You are spreading misinformation that the vaccine is the be all end all”, said resolution opponent Carolyn Strum.  “We should have the freedom for information. No one should have the right to control information.”

Supervisors’ Measure X Wish List

With the county expect to plow in $110 million in Measure X sales tax revenues, $23 million more than initially estimated prior to vote passage last November, supervisors began to reveal their funding priorities with the additional money that the county officials expect to flow into county coffers.

During a presentation from Measure X Community Advisory Board Chair Mariana Moore, supervisors indicated what county operations should receive Measure X funding priority for the upcoming 2022-2023 fiscal year.

Initially county officials expected the Measure X tax would drive in $87 million in revenues, but higher than expected consumer retail sales has pumped up the initial projection.

Code enforcement, transit, fire services, sheriff response and patrols were top Measure X priorities Supervisor Mitchoff listed. Mitchoff will serve as board chair next year, her final year in office.

Board vice chair Glover rattled off the office of racial justice and equity, the northern waterfront planning project, animal services, youth services center, and mental got top billing.

Trails and public transit were on District 2 Supervisor Candace Andersen’s Measure X list.

District 1 Supervisor John Gioia said county hospital, health clinics, transitionary housing and fire services especially in East County were on his Measure X list.

Improving fire services in East County, especially with the proposed consolidation for the Contra Costa County Fire District with the East Contra Costa County Fire District, was Chair Diane Burgis’ chief funding priority.

WHEREAS, Health misinformation has significantly undermined public health efforts and the unmitigated proliferation of health misinformation has created a culture of mistrust and has prolonged the COVID-19 pandemic, endangering the health and safety of all Contra Costa County residents and visitors; and

WHEREAS, The coronavirus (COVID-19) pandemic has resulted in over 95,000 cases and 921 deaths in Contra Costa County as of September 25, 2021; and

WHEREAS, The spread of COVID-19 has had a devastating impact on our health and safety, our regional economy, our elder residents, our communities of color, our mental health, the educational development of our children and every aspect of our lives; and

WHEREAS, In Contra Costa County, there are significantly lower vaccination rates for residents 20-29 years old, residents who identify themselves as White, Latinx (i.e. Latino/Hispanic), African-American, and more than one race/ethnicity, men, and in certain communities across the county and particularly in East and West County; and

WHEREAS, The COVID-19 vaccines have met the Food and Drug Administration’s (FDA) rigorous scientific standards for safety, effectiveness, and manufacturing quality and have been proven to be safe and effective; and WHEREAS, The Pfizer-BioNTech vaccine, brand name Comirnaty, has received full FDA approval and been proven to be highly effective in preventing serious disease, hospitalization and death from COVID-19 and that its benefits outweigh its risks; and

WHEREAS, The COVID-19 vaccine is available to everyone in Contra Costa County at no cost, regardless of income, residency within the county, health coverage or immigration status, and is administered by health professionals, like nurses and doctors; and

WHEREAS, misinformation has caused confusion and has led to eligible people declining COVID-19 vaccines, rejecting public health measures such as face coverings and physical distancing, and using unproven treatments; and

WHEREAS, On July 15, 2021, the United States Surgeon General issued his first advisory describing the “urgent threat” posed by the rise of false information of COVID-19 – one that continues to put “lives at risk” and prolong the pandemic; and

WHEREAS, Recent surges in infections and hospitalizations from COVID-19 in Contra Costa have highlighted the importance of clear and unequivocal communications from public officials that vaccines are the best protection against severe illness and hospitalizations; and

WHEREAS, Urgent action is needed to curb the spread of COVID-19 by combating misinformation, thereby supporting our healthcare system and saving lives; and

WHEREAS, There would be substantial detriment on Contra Costa County and its residents and visitors if not acted upon immediately; and

WHEREAS, Trusted community members, such as health professionals, faith leaders, educators, and leaders of Black, Indigenous, Latinx and other communities of color nationwide and in Contra Costa have spoken directly to their communities to address COVID-19 related questions by town halls, meetings, social media, and traditional media; and

WHEREAS, The Board of Supervisors and the County of Contra Costa is troubled by and actively discourages the spread of COVID-19 misinformation as it is a dangerous threat to public health; and

WHEREAS, Contra Costa Health Services continues to carry out its mission to care for and protect all Contra Costa County residents from COVID-19, especially our most vulnerable; and

WHEREAS, Contra Costa Health Services engages with our communities through building partnerships and trust with community organizations and residents, trusted messengers, and COVID-19 Ambassadors; and

WHEREAS, Contra Costa Health Services maintains a coronavirus website as a source of credible, up-to-date information regarding COVID-19 for Contra Costa residents at cchealth.org.

NOW, THEREFORE, BE IT RESOLVED, that the Board of Supervisors of Contra Costa County declares that COVID-19 health misinformation is an urgent public health crisis affecting our entire community and the County of Contra Costa commits to combating health misinformation and curbing the spread of falsehoods that threaten the health and safety of our residents; and

BE IT FURTHER RESOLVED the Board of Supervisors and the County of Contra Costa will develop and support policies and strategies that protect the health and safety of Contra Costa County residents through the promotion of evidence-based interventions, including face coverings and vaccination; and

BE IT FURTHER RESOLVED that Contra Costa Health Services will continue to share facts and scientific information about COVID-19, to correct misinformation including vaccine myths, to identify and give a platform to culturally relevant medical experts and trusted messengers, to respond to questions and requests for information on social media, and to work with our media and community partners to reach a broad audience with factual, timely information.

Allen Payton contributed to this report.

 

Pathways to Mental Health Services in Contra Costa County webinar October 21

Tuesday, October 12th, 2021

Contra Costa County and nonprofits are responding to the challenge of the growing emotional and mental health impacts of the pandemic. Learn about the pathways to mental health resources the county and nonprofits offer and the challenges to improve mental health outcomes as we seek to create a healthier community for everyone.

Join a Zoom webinar on October 21 from 4:00 p.m. to 5:30 p.m., where a panel will discuss the resources available.

Dr. Cindy Mataraso, Director of Clinical Services at Crestwood Behavioral Health, will moderate the panel.

Panelists include:

  • Rebecca Bauer Kahan, Member, California State Assembly
  • SuSun Kim, Director of the Family Justice Center, Contra Costa County
  • Dr. Suzanne Tavano, Director of Behavioral Health Services, Contra Costa County
  • Gigi Crowder, Executive Director of National Alliance on Mental Illness, Contra Costa County

Register at https://tinyurl.com/lwv-mental-health

The program is co-sponsored by the League of Women Voters of Diablo Valley, the League of Women Voters of West Contra Costa County and the Contra Costa County Library.  The Library will provide closed captioning for this event.

The program will be recorded and posted on the following sites after the meeting:

LWVDV YouTube channel

Contra Costa County Library YouTube channel

For more information contact: programs@lwvdv.org